Hiroki Taniguchi, PhD

Hiroki Taniguchi, PhD

Research Group Leader
Development and Function of Inhibitory Neural Circuits

One Max Planck Way
Jupiter, FL 33458
(561) 972-9000

Researcher Bio

Dr. Taniguchi was appointed a Research Group Leader of Development and Function of Inhibitory Neural Circuits Group at the Max Planck Florida Institute for Neuroscience in August 2012. His current research focus is to reveal fine connectivity of inhibitory neural circuits and understand the development and function of different GABA neuron subtypes.

Dr. Taniguchi received his Ph.D. in Developmental Neurobiology from the National Institute for Basic Biology (NIBB) in Japan. After his Ph.D., he started his postdoctoral work, also at NIBB, where he studied molecular and cellular mechanisms for neuronal migration in the hindbrain. Dr. Taniguchi then moved to the U.S.A. to work as a postdoctoral fellow at Columbia University, where he examined molecular mechanisms for synapse formation. From 2005 to 2012 he worked as a postdoctoral fellow (2005-2011) and a research investigator (2011-2012) in the lab of Dr. Z. Josh Huang at Cold Spring Harbor Laboratory. As a postdoctoral fellow, Dr. Taniguchi generated genetically engineered mouse lines to manipulate distinct subtypes of GABAergic inhibitory neurons, which enables researches to ask numerous unsolved questions about the complexity of neural circuits. Since 2011, Dr. Taniguchi has also been a researcher in Precursory Research for Embryonic Science and Technology in Japan.

Dr. Taniguchi has received grants from the National Alliance for Research on Schizophrenia and Depression (NARSAD) (2009), Citizens United United for Research in Epilepsy (CURE) (2013), and the Whitehall Foundation (2014).

Selected Publications

  1. Yetman, M.J., Washburn, E., Hyun, J.H., Osakada, F., Hayano, Y., Zeng, H., Callaway, E.M., Kwon, H.-B., and Taniguchi, H. (2019).  Intersectional monosynaptic tracing for dissecting subtype-specific organization of GABAergic interneuron inputs. Nature Neuroscience Online Publication.

  2. Ishino, Y., Yetman, M.J., Sossi, S.M., Steinecke, A., Hayano, Y., and Taniguchi, H. (2017). Regional Cellular Environment Shapes Phenotypic Variations of Hippocampal and Neocortical Chandelier Cells. J. Neurosci. 0047–17.

  3. Amat, S.B., Rowan, M.J.M., Gaffield, M.A., Bonnan, A., Kikuchi, C., Taniguchi, H., and Christie, J.M. (2017).  Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice. PLOS ONE 12, e0179347.

  4. Steinecke, A., Hozhabri, E., Tapanes, S., Ishino, Y., Zeng, H., Kamasawa, N., and Taniguchi, H. (2017). Neocortical Chandelier Cells Developmentally Shape Axonal Arbors through Reorganization but Establish Subcellular Synapse Specificity without Refinement. eNeuro 4, ENEURO.0057-17.2017.

  5. Wall, N.R., De La Parra, M., Sorokin, J.M., Taniguchi, H., Huang, Z.J., and Callaway, E.M. (2016). Brain-Wide Maps of Synaptic Input to Cortical Interneurons. J. Neurosci. 36, 4000–4009.

  6. Miyoshi, G., Young, A., Petros, T., Karayannis, T., McKenzie Chang, M, Lavado, A., Iwano, T., Nakajima, M., Taniguchi, H., Huang, Z.J., Heintz, N., Oliver, G., Matsuzaki, F., Machold, R.P., Fishell, G. (2015). Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cortical Interneurons. The Journal of Neuroscience 35, 12869-12889.

  7. Huang, Z.J., Taniguchi, H., He, M., Kuhlman, S. (2014). Cre-dependent adeno-associated virus preparation and delivery for labeling neurons in the mouse brain. Cold Spring Harbor Protocols. 2014 Feb 1;(2):190-4.

  8. Huang, Z.J., Taniguchi, H., He, M., Kuhlman, S. (2014). Genetic labeling of neurons in mouse brain. Cold Spring Harbor Protocols. 2014 Feb 1;(2):150-60.

  9. Taniguchi, H. (2014) Genetic dissection of GABAergic neural circuits in mouse neocortex Front. Cell. Neurosci. 8:8. PMCID: PMC3902216

  10. Basu, J., Srinivas, K.V., Cheung, S.K., Taniguchi, H., Huang, Z.J., Siegelbaum, S.A. (2014). A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow. Neuron. 2013 Sep 18;79(6):1208-21. PMCID: PMC3836574

  11. Nienborg, H., Hasenstaub, A., Nauhaus, I., Taniguchi, H., Huang, Z.J., Callaway, E.M. (2013). Contrast dependence and differential contributions from somatostatin- and parvalbumin-expressing neurons to spatial integration in mouse V1. J Neurosci. 2013 Jul 3;33(27):11145-54. PMCID: PMC3718383

  12. Li, H., Penzo, M.A., Taniguchi, H., Kopec, C.D., Huang, Z.J., Li, B. (2013). Experience-dependent modification of a central amygdala fear circuit. Nat Neurosci. 2013 Mar;16(3):332-9. PMCID: PMC3581751

  13. Kvitsiani, D., Ranade, S, Hangya, B., Taniguchi, H., Huang, J.Z., Kepecs, A. (2013). Distinct behavioural and network correlates of two interneuron types in prefrontal cortex.. Nature 498, 363-366.

  14. Taniguchi, H., Lu, J., and Huang, Z.J. (2013) The Spatial and Temporal Origin of Chandelier Cells in Mouse Neocortex Science. Jan 4;339(6115):70-4. PMCID: PMC4017638

  15. Adesnik, H., Bruns, W., Taniguchi, H., Huang, Z.J. and Scanziani, M. (2012) A Neural Circuit for Spatial Summation in the Visual Cortex Nature. Oct 11;490(7419):226-31. PMCID: PMC3621107

  16. Lee, S., Kwan, C.A., Zhang, S., Phoumthipphavong, V., Flannery, G.J., Masmanidis, C.S., Taniguchi, H., Huang, J.Z., Zhang, F., Boyden, S.E., Deisseroth, K., and Dan, Y. (2012) Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature. Aug 16;488(7411):379-83. PMCID: PMC3422431

  17. Gentet L.J, Kremer Y, Taniguchi H, Huang Z.J, Staiger J.F, and Petersen C.C. (2012) Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex. Nat Neurosci. 2012 Feb 26;15(4):607-12.

  18. Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsiani, D., Fu, Y., Lu, J., Lin, Y., Miyoshi, G., Shima, Y., Fishell, G., Nelson, S., and Huang, Z.J. (2011). A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex. Neuron. 2011 Sep 22;71(6):995-1013. PMCID: PMC3779648

  19. Miyamichi, K., Amat, F., Moussavi, F., Wang, C., Wickersham, I., Wall, R.N.,Taniguchi, H., Tasic, B., Huang, Z.J., He, Z., Callaway, M.E., Horowitz, A.M., Luo, L. (2011). Cortical representation of olfactory bulb input revealed by retrograde mono-transsynaptic labeling. Nature. Apr 14;472(7342):191-6. PMCID: PMC3073090

  20. Taniguchi, H., Gollan, L., Scholl, F., Mahadomrongkul, V., Dobler, E., Limthong, N., Peck, M., Aoki, C., and Scheiffele, P. (2007). Silencing of Neuroligin Function by Postsynaptic Neurexins. Journal of Neuroscience. 2007 Mar 14;27(11):2815-24. PMCID: PMC2839889

  21. Taniguchi, H., Kawauchi, D., Nishida, K., and Murakami, F. (2006). Classic Cadherins Regulate Tangential Migration of Precerebellar Neurons in the Caudal Hindbrain. Development. 133(10):1923-31.

  22. Kawauchi, D., Taniguchi, H., Watanabe, H., Saito, T., and Murakami, F. (2006). Direct Visualization of Nucleogenesis by Precerebellar Neurons: Involvement of Ventricle-Directed, Radial Fibre-Associated Migration. Development. 133(6):1113-23.

  23. Taniguchi, H., Tamada, A., Kennedy, T. E., and Murakami, F. (2002). Crossing the Ventral Midline Causes Neurons to Change Their Response to Floor Plate and Alar Plate Attractive Cues during Transmedian Migration. Developmental Biology. 249(2):321-332.

  24. Taniguchi, H., Shishido, E., Takeichi, M., and Nose, A. (2000). Functional Dissection of Drosophila Capricious: Its Novel Roles in Neuronal Pathfinding and Selective Synapse Formation. Journal of Neurobiology. 42(1):104-116.

  25. Taniguchi, H., Tohyama, M., and Takagi, T. (1996). Cloning and Expression of a Novel Gene for a Protein with Leucine-rich Repeats in the Developing Mouse Nervous System. Molecular Brain Research. 36(1):45-52.