Jason Christie, PhD

Jason Christie, PhD

Research Group Leader
Mechanisms of Synaptic Signaling and Computation

One Max Planck Way
Jupiter, FL 33458
(561) 972-9410

Researcher Bio

Dr. Christie joined the Max Planck Florida Institute in July 2010 as Research Group Leader in Synaptic Signaling and Computation. Prior to this appointment, Dr. Christie conducted research at the Vollum Institute at the Oregon Health and Science University in Portland, Oregon, where he completed his doctoral and post-doctoral work. He has joint faculty appointments with Scripps Florida and Florida Atlantic University.

Selected Publications

  1. Gaffield, M.A., Bonnan, A., and Christie, J.M. (2019). Conversion of Graded Presynaptic Climbing Fiber Activity into Graded Postsynaptic Ca2+ Signals by Purkinje Cell Dendrites. Neuron. Online Publication.

  2. Michaelson*, S.D., Ozkan*, E.D., Aceti, M., Maity, S., Llamosas, N., Weldon, M., Mizrachi, E., Vaissiere, T.,  Gaffield, M.A., Christie, J.M., Holder, J.R., Miller, C.A., and Rumbaugh, G. Nat. Neurosci. 21, 1-13. (2018) SYNGAP1 heterozygosity disrupts sensory processing by reducing touch-related activity within somatosensory cortex circuits

  3. Gaffield, M.A., Rowan, M.J.M., Amat, S.B., Hirai, H., and Christie, J. (2018).  Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements. eLife, 7:e36246.

  4. M.A., Rowan*, Bonnan, A.*, Zhang, K.*, Amat, S.B., Kikuchi, C., Taniguchi, H., Augustine, J.G., and Christie, J.M. (2018). Graded Control of Climbing-Fiber-Mediated Plasticity and Learning by Inhibition in the Cerebellum.  Neuron, 99, 999-1015.

  5. Amat, S.B., Rowan, M.J.M., Gaffield, M.A., Bonnan, A., Kikuchi, C., Taniguchi, H., and Christie, J.M. (2017).  Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice. PLOS ONE 12, e0179347.

  6. Gaffield, M.A., and Christie, J.M. (2017). Movement Rate Is Encoded and Influenced by Widespread, Coherent Activity of Cerebellar Molecular Layer Interneurons. J. Neurosci. 37, 4751–476.

  7. Rowan, J.M. and Christie, J.M. (2017). Rapid State-Dependent Alteration in Kv3 Channel Availability Drives Flexible Synaptic Signaling Dependent on Somatic Subthreshold Depolarization. Cell Reports 18, 2018–2029.

  8. Rowan, M.J.M., DelCanto, G., Yu, J.J., Kamasawa, N., and Christie, J.M. (2016). Synapse-Level Determination of Action Potential Duration by K+ Channel Clustering in Axons. Neuron, 91, 370-383.

  9. Gaffield, M.A., Amat, S.B., Bito, H., and Christie, J.M. (2015). Chronic imaging of movement-related Purkinje cell calcium activity in awake behaving mice. J. Neurophysiol. 155, 413-422.

  10. Rowan M.J., Tranquil E., Christie J.M. (2014). Distinct Kv channel subtypes contribute to differences in spike signaling properties in the axon initial segment and presynaptic boutons of cerebellar interneurons. J. Neurosci. 34, 6611-23.

  11. Christie, J.M., Chiu, D.N., Jahr, C.E. (2011). Ca2+-dependent enhancement of release by subthreshold somatic depolarization. Nat. Neurosci. 14: 62-68.

  12. Christie, J.M. and Jahr, C.E. (2009). Selective expression of ligand-gated ion channels in L5 pyramidal cell axons. J. Neurosci. 29, 11441-11450.

  13. Christie, J.M. and Jahr, C.E. (2008). Dendritic NMDA receptors activate axonal calcium channels. Neuron. 60, 298-307.

  14. Christie, J.M. and Westbrook, G.L. (2006). Lateral excitation within the olfactory bulb. J. Neurosci. 26, 2269-2277.

  15. Christie, J.M. and Jahr, C.E. (2006). Multivesicular release at Schaffer Collateral-CA1 hippocampal synapses. J. Neurosci. 26, 210-216.

  16. Christie, J.M., Bark, C., Hormuzdi, S.G., Helbig, I., Monyer, H., and Westbrook, G.L. (2005).  Connexin36-mediated spike synchrony in olfactory bulb glomeruli. Neuron. 46: 761-772.

  17. Christie, J.M. and Westbrook, G.L. (2003). Regulation of backpropagating action potentials in mitral cell lateral dendrites by A-type potassium currents. J. Neurophysiol. 89, 2466-2472.

  18. Christie, J.M., Schoppa, N.E., and Westbrook, G.L. (2000). Tufted cell dendrodendritic inhibition in the olfactory bulb is dependent on NMDA receptor activity. J. Neurophysiol. 85, 169-173.

  19. Jane, D.E., Tse, H.-W., Skifter, D.A., Christie, J.M., and Monaghan D.T. (2000). Glutamate receptor ion channels: activators and inhibitors. in Handbook of Experimental Pharmacology: Pharmacology of Ionic Channel Function: Activators and Inhibitors (Endo, M., Mishina, M., and Kurrachi, Y. eds), Springer, Berlin.

  20. Christie, J.M., Jane, D.E., and Monaghan, D.T. (2000). Native N-Methyl-D-Aspartate receptors containing NR2A and NR2B subunits have pharmacologically distinct competitive antagonist binding sites. J. Pharmacol. Exp. Ther. 292, 1169-1174.

  21. Christie, J.M., Wenthold, R.J., and Monaghan, D.T. (1999). Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in the rat hippocampus. J. Neurochem. 72, 1523-1528.

  22. Brown, J.C. 3rd, Tse, H.W., Skifter, D.A., Christie, J.M., Andaloro, V.J., Kemp, M.C., Watkins, J.C., Jane, D.E., and Monaghan, D.T. (1998).  [3H]homoqunolinate binds to a subpopulation of NMDA receptors and to a novel binding site.  J. Neurochem. 71, 1464-1470.