McLean Bolton, PhD

McLean Bolton, PhD

Research Group Leader
Disorders of Neural Circuit Function

One Max Planck Way
Jupiter, FL 33458
(561) 972-9000

Visit McLean Bolton's Lab Website

Researcher Bio

Dr. M. McLean Bolton started her research program at Max Planck Florida Institute for Neuroscience as an independent Research Group Leader focusing on disorders of neural circuitry in January of 2011. Prior to this appointment, she was a Research Assistant Professor in the Department of Pediatrics, Division of Neurology at Duke University Medical Center (2008-2010).

Dr. Bolton’s early postgraduate career was in ion channel drug discovery and developing high content screening platforms for neurological disorders (2000-2008). Before returning to basic research in 2008, she worked as a Research Scholar for the Duke Drug Discovery Center, a Senior Scientist at Icagen, Inc., a Scientist II at Amphora Discovery Corporation, and an Investigator at Cogent Neuroscience, Inc.

She received her PhD in Neurobiology at Duke University in 2000 for her work on the regulation of excitatory and inhibitory synaptic transmission in hippocampal cultures by brain-derived neurotrophic factor. Her thesis work was supported by an individual National Research Service Award.

Selected Publications

  1. Baker, C.A., Elyada, Y.M., Parra, A., and Bolton, M.M. (2016). Cellular resolution circuit mapping with temporal-focused excitation of soma-targeted channelrhodopsin. eLIFE 5, e14193.

  2. Kaltenbach*, L.S., Bolton*, M.M., Shah, B., Turmel, G. J., Kanju, P.M., Lewis, G.M., Turmel, G. J., Trask, O. J. and D. C. Lo (2010) Cortico-Striatal Co-Cultures: A High-content Screening Platform for Huntington’s Disease. Journal of Biomolecular Screening, 15, 806-19.

  3. Bolton, M.M. and C. Eroglu (2009). Look who is weaving the neural web: glial control of synapse formation. Current Opin. Neurobiol., 19, 491-7.

  4. Bolton, M.M., A.J. Pittman, and D.C. Lo (2000) Brain-Derived Neurotrophic Factor Differentially Regulates Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures. J. Neurosci. 20, 3221-3232.

  5. Bolton, M.M., Blanpied, T.A., and M.D. Ehlers (2000). Membrane targeting of ionotropic glutamate receptors. Cell and Molecular Life Sciences, 57, 1517-1525.

  6. Bolton, M.M., D.C. Lo, and N.T. Sherwood (2000). Regulation of excitatory and inhibitory synaptic transmission in hippocampal cultures by brain-derived neurotrophic factor. Prog. Brain Res., 128, 203-218.

  7. Renard, D.C., M.M. Bolton, B. Margolis, A. Zilberstein, J. Schlessinger, S.G. Rhee and A.P. Thomas (1992). Overexpression of phospholipase C alpha modifies the kinetics of PDGF- induced calcium increases in NIH-3T3 cells. Biochem. J. 281, 775-784.

  8. Thomas, A.P., G. Stewart, M.M. Bolton, S.T. Conohan and D.C. Renard (1991) Effects of ethanol and cocaine on electrically triggered calcium transients in cardiac muscle cells. Ann. N.Y. Acad. Sci., 625, 395-408.